ANTI-AGING / WRINKLES

  In use since the 1950’s, metformin is ADA’s recommended first line treatment for management of type 2 diabetes and one of my all time favorite medications to prescribe.  Aside from its highly effective anti-diabetic virtue, metformin has been implicated in cancer prevention, weight loss, and PCOS.  In animal models, metformin has proven to expand lifespan.  When indicated, I find myself reverting to this medication time and time again for both it ease of use, tolerability, cost and anti-aging properties. 

  Astonishing findings of a new anti-diabetic medication, empagliflozin shocked the medical community with results of trial showing 32% reduction in mortality in diabetics who took  this pill in addition to standard regimen.  In other words, patients had 1-in-3 chance of avoiding death with Jardiance.  Contrary to most other anti diabetic agents, which act on insulin metabolism in the liver or pancreas, empagliflozin works on the kidney by blocking the reabsorption of glucose from urine into blood via a kidney tubule receptor known as sodium glucose co-transporter (SGLT-2 ). 

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